June 12th, 2025: EMA Links Semaglutide to Rare Vision Disorder The European Medicines Agency (EMA) has formally acknowledged a potential link between semaglutide, the key ingredient in Ozempic, Wegovy, and Rybelsus, and a rare but serious eye condition known as non-arteritic anterior ischemic optic neuropathy (NAION)
### The STEP 5 Study: Long-Term Adherence The STEP 5 two-year extension study (*Nature Medicine*, 2022) showed: - Patients who maintained consistent dosing for 2 years sustained an average weight loss of 15.2% - Adherence was the strongest predictor of long-term success - Patients who missed occasional doses (but did not discontinue) still achieved meaningful results - The difference between "perfect" adherence and "good" adherence (missing 12 doses per quarter) was relatively small **Key takeaway**: Don't panic about occasional missed doses
People taking the drugs in real-world settings appear to be more likely to quit taking the meds, researchers said
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Study on the mechanism of glucocorticoid receptor mitochondrial translocation and glucocorticoid-induced apoptosis in macrophages
