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However, thicker skin may require formulations designed for body use, and results may vary depending on skin sensitivity and exposure to sun or friction

doi: 10.1007/BF01126554 50 VeraverbekeW

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A solution to induce an acute hepatic toxicity and a rapidly progressing encephalopathy with severe seizures in rats may be a single paracetamol overdose (5 g/kg intraperitoneally) that excided the regimens previously used (1, 2, 6, 11)