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More serious manifestations of hypermagnesaemia, typically occurring only with very high doses or in those with renal impairment, include hypotension, bradycardia, respiratory depression, and altered mental status

Acknowledgements We also thank Figdraw (www.figdraw.com) for the assistance in creating figures

A., Danska, J

As of September 2023 it is on the FDA's Category 2 list of bulk drug substances that may not be compounded due to significant safety risks, and the agency has scheduled a Pharmacy Compounding Advisory Committee (PCAC) review for July 2026 covering proposed uses in opioid withdrawal, chronic insomnia, and narcolepsy