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Continuous ROS production results in oncogene and tumor suppressor gene changes, as well as chromosomal abnormalities by oxidative genome damage, which includes the oxidation of guanine to form 8-OhdG and 8-oxo,7,8-dihydroguanosine (8-OHG) in RNA and DNA (100)

Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes

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The effect of the early-life environment on adult developmental programming, particularly at mid-childhood, has been reported [8, 9] and was evident in a series of studies on Bangladeshi migrants whose reproductive phenotype was associated with whether they had grown up in Bangladesh or the UK [10, 11]