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If dosing is too high or continuous without breaks, the body will downregulate its own endogenous pathways and could become dependent or have blunted natural hormone production

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When LPS enters the bloodstream, it strongly activates the immune system, leading to the massive release of pro-inflammatory cytokines and the generation of large amounts of ROS, ultimately resulting in hepatocyte death and acute liver injury (Zhang G

Adaptive mechanisms, including hypertrophy, decrease in vascular resistance and tubular reabsorption in remaining nephrons, allow maintenance of internal homeostasis, even when the kidney mass is reduced to 2025% of normal (Hall & Hall, 2020)