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According to the FDA prescribing information, tirzepatide is not recommended for patients with severe gastrointestinal disease, such as severe gastroparesis
Its safety profile is generally favorable, but several specific considerations deserve clinician attention particularly around copper biology, zinc balance, and the small number of patient populations where caution or contraindication applies
One of the advantages Holst's group had in working on the issue was that researchers in Copenhagen were skilled at keeping pancreases alive that had been removed from pigs by perfusion with artificial blood
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