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Description

Notably, in erythroid cells, caspase-3 activation does not guarantee apoptosis execution, since the transcriptional factor GATA-1 essential for erythropoiesis is protected from caspase-3 by HSP70 (heat shock protein 70)

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Humans and rodents with IGF-1 or IGF-1 receptor gene mutations demonstrate significant growth restriction (Woods et al., 1996

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Importantly, food intake remained unchanged in treated animals, suggesting the compound's effects relate to energy expenditure pathways rather than appetite

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