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When compared with placebo or other therapies, GLP-1 agonists were associated with an increased risk of biliary disease [23]: Overall biliary disease: RR 1.37(95% CI 1.231.52) Cholelithiasis: RR 1.27 (95% CI 1.101.47) Cholecystitis: RR 1.36 (95% CI 1.141.62) Mechanisms: Reduced gallbladder motility Rapid weight loss increased cholesterol saturation and gallstone formation

The daily versus weekly application creates an adherence difference that can explain part of the effect differences in real-world data

Quick Tip: Switch thighs each week to let the skin rest

Always visit a qualified practitioner and always do your research sometimes new isnt always best and treatment longevity, how long a treatment has been around, is the greatest indicator of safety

"Safety Alerts for Human Medical Products Chantix (varenicline) and Zyban (bupropion)"