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Mitochondrial GR is essential for: Protecting the electron transport chain components from oxidative damage Maintaining mitochondrial DNA integrity against oxidative lesions Supporting ATP production by preserving mitochondrial membrane potential Preventing mitochondrial-initiated apoptosis triggered by excessive oxidative stress Facilitating mitochondrial glutathione transport and utilization The mitochondrial glutathione system is particularly critical in neurons and other cells with high energy demands, where mitochondrial dysfunction can have catastrophic consequences

Souleymane Ciss, 84

Independent researchers determine mitochondrial test is unreliable and should not be used as test in ME/CFS | 09 August 2019: The ME Association

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The investigators didnt attempt to control for weight loss effects by imposing calorie restriction or other weight-matching strategies on the placebo group, nor did they perform any analyses on their data that might correct for the weight loss discrepancy