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Srenson's thinking was coloured by the fact that a previous drug, Redux, approved in 1996 by the FDA for weight loss and launched with great fanfare, had to be withdrawn a year later after it was found to cause major heart attacks and to be largely ineffective

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Short DNA sequences found in the regulatory regions of hypoxia-inducible genes, which allow for their transcriptional activation by hypoxia-inducible factors when cellular oxygen levels are low, thereby promoting cellular adaptation to hypoxic conditions