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DISCUSSION In this NMA, GLP-1RA had a significantly better effect in reducing liver fat content and improving cardiometabolic risk parameters, including BMI and WC, in overweight or obese patients with NAFLD or NASH

A secondary mechanistic analysis of the SUMMIT trial found associations between tirzepatide treatment and reductions in circulatory volume and markers of cardiac injury [85]

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the maximal increase in blood pressure was observed toward the end of the infusion

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