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doi:10.1146/annurev-nutr-120524-043056 Quinn M, Halsey J, Sherliker P, et al

Description BPC-157 BPC-157 (Body Protection Compound 157) is a synthetic pentadecapeptide studied in preclinical models for its roles in tissue repair signaling, angiogenesis, nitric oxide modulation, and gastrointestinal mucosal research

Phase 2 trial data for the CagriSema combination (cagrilintide 2.4mg + semaglutide 2.4mg) demonstrated approximately 15.6% mean weight reduction at 32 weeks substantially exceeding semaglutide alone and positioning amylin/GLP-1 dual agonism as a competitive research frontier alongside GIP/GLP-1 and triple agonist approaches

The animal studies that generated excitement about BPC 157 almost universally used intraperitoneal or subcutaneous injection, not intranasal spray

A recent study utilized 16S rRNA sequencing to examine the gut microbiota composition in HFD-fed ApoE / mice