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This apoptotic effect can be rescued by cholesterol supplementation but not by lanosterol, highlighting the functional importance of downstream cholesterol synthesis in cell survival [7]

Additional research is exploring its influence on oxidative stress response, immune modulation, and cellular communication involved in tissue repair and remodeling

Arrese, M., et al., Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

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Collectively, while ferroptosis plays a significant role in the pathogenesis of both TMJ OA and KOA, the specific effects may differ due to the distinct tissue characteristics, mechanical stress, and inflammatory environments of TMJ and knee