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Incretins, the current standard of care for obesity, have drawbacks including GI-side effects, rebound after cessation of treatment, and lean mass loss (140, 159, 160)
DDIs occur when one drug alters the pharmacokinetics or pharmacodynamics of another, leading to: Increased toxicity Reduced efficacy Unexpected clinical outcomes Most clinically relevant DDIs are mechanism-driven, not accidental
In one the most commonly used models of skin fibrosis induced by intracutaneous injections of bleomycin, MSH also showed potential therapeutic effect by reducing skin thickness, collagen content and expression of superoxide dismutase 2 (SOD2) and heme oxygenase 1 (HO-1) (161)
Potential side effects (usually related to the benzyl alcohol preservative) include: Allergic reactions (rare) Local irritation at injection site In neonates or very small infants, benzyl alcohol can cause toxicity (gasping syndrome) and should NOT be used