In our GBM models, depletion of the cellular NADH pool resulting from the combined treatment of sertraline and chloroquine might enhance the sensitivity of resistant GBM cells to chloroquine by increasing the availability of the NADH-binding pocket to exert its function
To enhance bioavailability in the market, which is now 1% instead of the 5-10% of oral therapies, pharmaceutical companies are now developing various next-generation oral delivery platforms including enteric-coated formulations, nanoparticle carriers, and absorption enhancers, to make oral GLP-1 therapy more feasible and cost-effective
The data were processed via Biacore T200 Evaluation Software v3.2 (Cytiva) and 1:1 binding model analysis
The NEC Lawsuits target Abbott Laboratories and Mead Johnson & Company, the manufacturers of Similac Infant Formula and Enfamil Infant Formula respectively
The section was then counterstained with hematoxylin (Sigma-Aldrich) and mounted with DPX, a synthetic non-aqueous mounting medium for microscopy
