Preclinical studies have demonstrated that both glycyrrhizin and silymarin exert hepatoprotective effects against oxidative stress, and their combination may produce synergistic benefits by reducing serum transaminases and enhancing antioxidant enzyme activities ( 5 Adverse reactions Pseudohyperaldosteronism is the most common adverse reaction
Mishra, M., Singh, R., Mukherjee, S
In 2023, both were placed on a list of substances considered high-risk for compounding
In these lipid-based systems, lipophilic compounds preferentially dissolve in the hydrophobic compartment of surfactants composing micellar or vesicular structures and/or within the oil compartment of emulsions and lipid nanoparticle systems, thereby increasing their solubility in aqueous solution
Immunity (2007) 26(2):24155