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Further, lower levels of IL-12 and TNF-, along with higher levels of the anti-inflammatory cytokine IL-10 have been observed (Chang et al

Similar content being viewed by others Introduction Epigenetic regulation of gene expression refers to chromatin-based mechanisms that do not introduce changes in the DNA sequence per se and is not necessarily heritable

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Conclusion: Conclusively, PA can be considered a potential compound that can attenuate acetaminophen-induced hepatotoxicity through its role as an iron chelator and antioxidant, as well as the up-regulation of SIRT -1 and down-regulation of CYP2E1

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