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The first stage (Norwood procedure) is performed in the neonatal period and involves division of the main pulmonary artery and ligation of the ductus arteriosus, removal of the atrial septum and reconstruction of a new ascending aorta using the proximal main pulmonary artery and the ascending aorta

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At follow up visits two years later, their levels of 5MTHF in their CSF had dropped even further

The before and after photos look compelling

however, the two enzymes have different roles in metabolism and different intracellular locations