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The unpaired t test for differential abundance with a standard two-tailed and two-sample t test was performed using mattes function in MATLAB on each metabolite to calculate the Wilcoxon t statistic for two groups being compared

FOXA1 can promote the expression of E-cadherin, while BACH1 inhibits the expression of FOXA1 and genes critical for epithelial cell adhesion, including claudin3 and claudin4, thus promoting the EMT

Although the position of these side chains was altered, K1002 and R962 retained electrostatic interactions with residues E151 and D146, respectively, in 1907

These results suggest that the upregulation of tribbles homolog 3 protein (TRB3) due to diabetes results in impaired cardiac glucose metabolism via the inhibition of cardiac Akt2 function

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