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Semaglutide and tirzepatide trials demonstrate 5-22% body weight reduction in sedentary or minimally active participants, though individual results vary based on metabolic factors, adherence, and baseline health status

10.3389/fphar.2023.1205207 Front

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By 48 weeks, significant average weight loss was seen at all maintenance doses: With longer treatment lasting up to 68 weeks, weight loss continued, particularly at higher doses: 12mg: average weight loss of up to 28.7% of body weight This longer-term data shows that weight loss with retatrutide can continue beyond one year, rather than plateauing early, especially at higher maintenance doses