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Nevertheless, because midazolam and the majority of benzodiazepines are mainly metabolized in the liver, its metabolic rate can decrease in patients with cirrhosis

The medium was collected into 1.5 ml tubes, centrifuged for 2 min at 3000 g and kept at 80 C for measurement of GnRH in the supernatant by ELISA (Phoenix Pharmaceuticals, catalog # EK-040-02 CE), according to the manufacturers protocol

Notably, the extent of migration enhancement by these EVs was similar to that induced by native FBS-containing EVs, indicating that EVs were responsible for the observed increase in cell migration (Supplementary Fig

In-network and out-of-network coverage is the patients responsibility

To visualize protein structures, we used UCSF ChimeraX (v.1.9) 52