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While drinking coffee increased the growth of beneficial bacteria in humans and rats, frequent enemas may reduce their number by washing them off and prevent their regrowth due to the acidity of coffee [19, 20]

Nordin M, Bergman D, Halje M, Engstrom W, Ward A

No consistent pattern was seen with the median t max across the groups (72, 48, 48 and 60 h for normal renal function and mild, moderate and severe renal impairment, respectively)

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