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As an example, we can take the first option for every step in the Embden-Meyerhof pathway definition from above: ( K00844 ,K12407,K00845,K00886,K08074,K00918) ( K01810 ,K06859,K13810,K15916) ( K00850 ,K16370,K21071,K00918) ( K01623 ,K01624,K11645,K16305,K16306) K01803 (( K00134 ,K00150) K00927 ,K11389) ( K01834 ,K15633,K15634,K15635) K01689 ( K00873 ,K12406) to get the following path of KOs (which happens to be the first path shown in the output example below): K00844 K01810 K00850 K01623 K01803 K00134 K00927 K01834 K01689 K00873 In summary, a path is one set of enzymes that can be used to catalyze all reactions in a given metabolic pathway, and there can be many possible paths (containing different sets of alternative enzymes) for a module

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10.1186/s12974-019-1653-7 180 Liu-AmbroseT.NagamatsuL

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