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31 Tips for safer colchicine use: 8, 26, 28 Prescribe the lowest effective dose and provide clear instructions on how and when to take it Advise patients to stop taking colchicine and seek medical attention if they experience nausea, vomiting, diarrhoea or abdominal pain Limit prescriptions to the anticipated number of tablets required for managing an acute attack of gout

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(1,2) It is also a precursor of the brain neurotransmitter glutamate

J Physiol Pharmacol 2004