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A formulation patent worth, hypothetically, $500 million in protected revenue under pre-IRA pricing assumptions might be worth $150 million under post-IRA MFP-constrained assumptions

Sargatal, D

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The signal is subsequently transmitted to the nucleus by the c-Jun, ELK-1 and STAT3 transcription factors, and different transcription factors bind to different sites of the PD-L1 promoter to form multiprotein complexes