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Methylthioadenosine (MTA) regulates liver cells proteome and methylproteome: implications in liver biology and disease

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Compounding pharmacies would be able to prepare them again under physician prescription within weeks

Clinical outcome: Mucositis, stomatitis Severe myelosuppression (anaemia, leukopenia, thrombocytopenia) Nephrotoxicity, hepatotoxicity Life-threatening infections, bleeding High-risk groups: Elderly Patients with renal impairment Patients on high-dose methotrexate (oncology use) Concomitant nephrotoxic drugs Advice: Avoid NSAIDs with high-dose methotrexate