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doi: 10.1016/j.clinre.2012.06.006 69 CanyellesMTondoMCedLFarrsMEscol-GilJCBlanco-VacaF

The most detailed population-level analysis comes from Wharton et al., published in Diabetes, Obesity and Metabolism in 2021, which pooled data from the STEP 13 trials

Fat-rich diets, for instance, elicit hypothalamic inflammation (reactive activation and proliferation of microglia, a condition named gliosis)

Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells, and its inhibition slows cell growth

Wegovy (semaglutide 2.4 mg) is a prescription-only medicine licensed by the MHRA and recommended by NICE for weight management in specific patient groups