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The rest of the almost 3% of people who have immunodeficiencies have secondary immunodeficiencies.Infectious diseases (such as HIV), malnutrition, age, surgery, environmental stress, and immunosuppressive drugs can all cause secondary immunodeficiency

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In addition, selenium serves as a cofactor of glutathione peroxidase 4 (Gpx4) that inhibits lipid peroxidation, resulting in the attenuation of ferroptosis 17

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