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Toxin and drug exposure Some also hypothesise that toxin exposure could trigger ME/CFS (61), such as organophosphate compounds (152, 153) and heavy metals (154)

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Furthermore, PGC-1 suppresses the transport of NF-B p65 from the cytoplasm to the nucleus and the degradation of IB by regulating NF-B, thereby reducing A-induced neuronal death and inhibiting neuroinflammation, which in turn reduces mitochondrial damage and restores AD cognitive deficits (Zhang Y