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In topical application, studies use concentrations of 0.01-1% in cream or serum formulations (Pickart et al., BioMed Res Int 2015For subcutaneous injection (research), doses vary depending on the experimental model

However, its a complaint you might hear quite often

Severe Allergic Reactions: Anaphylaxis Anaphylactic reactions, although rare, are serious side effects of Vitamin B12 injections

The NICE recommendations tell GPs to consider testing in anyone with one symptom or one risk factor, and to treat early to prevent neurological damage that can become permanent