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Oxidative stress is the state induced by an overbalance in the form of excess ROS, and can be a causative factor in chronic wound formation 15 , as well as in the pathogenesis of other diseases including cancers, cardiovascular diseases, Parkinsons, obesity, and other clinically-relevant age-related diseases 54,55,56,57

Vitamin B12 deficiency is relatively common, especially when on a restricted diet

The drug 5-FU was administrated daily at a dose of 30 mg/kg intraperitoneally, while normal saline was used as a control

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Castro and Strange (1993) FEBS Lett