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Naturally occurring GLP-1R peptide agonists share a conserved N-terminal sequence with GLP-1, including oxyntomodulin and the first FDA approved GLP-1R agonist, exendin-4 (Figure 1A)

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GLP-1 receptor agonists semaglutide, liraglutide, dulaglutide and the GIP/GLP-1 dual agonist tirzepatide act on appetite, satiety, and gastric emptying