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Differences in study design, age of patient population, measured outcomes, and treatment dosage and duration likely contribute to inconsistent findings (Table 1)

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Cytokine profiling revealed that only HA + GSH-C4 elicited significant modulation of tear mediators, and post-treatment cytokine levels correlated directly with other clinical metrics, consistent with a glutathione-mediated rebalancing of the ocular surface microenvironment

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