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mBio 5:e01251e01214 LaRocca TJ, Stivison EA, Mal-Sarkar T et al (2015) CD59 signaling and membrane pores drive syk-dependent erythrocyte necroptosis

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The most common minor side effects are slight orange skin tinting at very high doses (harmless and reversible) and occasional GI discomfort

Indeed, such abnormal presence of mitochondria in circulating red blood cells causes increased oxygen consumption, ROS generation, and hemolysis in SCD patients 50,51

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