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Recent studies suggest that treatment with semaglutide (GLP-1RA) in combination with firsocostat (ACC-a inhibitor) and/or cilofexor (nonsteroidal FXR agonist) can further improve hepatic steatosis and thus NAFLD compared with semaglutide alone in exploratory efficacy analyses [113]

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Who genuinely qualifies, and who should avoid them

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In women, significant weight loss may impact oestrogen levels, whilst in men, testosterone levels may be affected

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The increasing recognition of obesity as a chronic disease requiring medical intervention has encouraged broader adoption of GLP-1 therapies

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Neuropharmacology 28 , 829835 (1989)

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