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Heres how specific conditions can impact the use of B12 shots: Heart Disease: While B12 is essential for overall health, excessive amounts of vitamin B12 in the body may sometimes cause an increase in certain heart disease risk markers, particularly for individuals with pre-existing cardiovascular conditions

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Whilst true toxicity from too much vitamin B12 is exceptionally rare due to the body's natural excretion mechanisms, elevated B12 levels can occur and may signal underlying health conditions

However, using variants that do not dimerize, it has been recently described that homodimer formation of GCL is not required for enzyme activation (Yang et al., 2019)