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Step 3: MTHF releases its methyl group via vitamin B12 to the methionine cycle, which produces THF again and restarts the cycle

These copper ions inhibit type 1 5-alpha reductase by up to 90% in vitro (Sugimoto et al., 1995), reducing local DHT production

However, the BfR recommends limiting the daily intake to a maximum of 9 g, i.e