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To keep the broadened substrate scope, ALOX12/15 can be reactive towards intact PLs which do not require the PLs hydrolysis for peroxidation

The same stimulus was then applied to the operated right hind limb and was graded on a scale of 0-3 in comparison to the left hind limb response

While these findings support that choline may protect the kidneys during sepsis, the survival rate was not affected by choline supplementation (245)

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In fact, the levels of oxo-8-deoxyguanosine, which is considered to be the major oxidative damage to DNA, have been found correlated linearly with oxidation of glutathione [107]