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Gomez-Gallego, F., Garrido-Pertierra, A

[214] For chronic sleep disorders such as delayed sleep phase syndrome or persistent insomnia, nightly use may be appropriate under medical supervision

Functional factors with a nutritional basis operate predominantly through energy metabolism optimization, calcium homeostasis maintenance, and regulation of protein synthesis, whereas functional factors derived from natural extracts exert their effects more through multitarget synergistic mechanisms, including antioxidant and anti-inflammatory action, immune enhancement, gut microbiota regulation, and muscle fiber type transformation

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Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo