glp-1 gpcr GLP-1R and Diabetes β-cell GPCR activation by GLP-1,

By normalizing or increasing the efficiency of glucose metabolism, thiamine decreases the degradation of amino acids as energy substrates and increases protein synthesis, which is essential for maintaining tight junctions and intestinal barrier integrity (194)

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The former provides rapid onset GH release while the latter acts to raise GH secretion over longer periods and maintain normal physiologic secretion patterns [8], [9]

Journal of Pharmacy and Pharmacology 53:171120

Acknowledgments The authors acknowledge the subjects for their participation as well as our colleagues in the Kinesiology Department of Tarbiat Modares University who helped with data collection