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Combined, the two approaches (NNMT inhibition + precursor supplementation) theoretically produce synergistic NAD+ restoration

The principle of this reaction is based on the reaction between the thiol group (-SH) of glutathione and the DTNB reagent, which results in the formation of a colored product

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Appl Surf Sci 465:303312 He T, Zhang YQ, Chen Y, Zhang ZZ, Wang HY, Hu YF et al (2019b) Single iron atoms stabilized by microporous defects of biomass-derived carbon aerogels as high-performance cathode electrocatalysts for aluminum-air batteries