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More significantly, we were able to link ACTL6A with NRF2-related antioxidant pathway, and to link NRF2 with ferroptosis

Recycling & Regulation Glutathione can be regenerated from its oxidized form (GSSG) back into its active state (GSH) with the help of NADPH

Long et al., 2024), including the NADPH/FSP1/CoQ10 pathway, the dihydroorotate dehydrogenase (DHODH) pathway, the GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4)/dihydrofolate reductase (DHFR) pathway, the membrane-bound O-acyltransferase 1/2 (MBOAT1/2) pathway, the peroxiredoxin 6 (PRDX6) pathway, and the 7-dehydrocholesterol (7-DHC) pathway

& Stoyanovsky, D

Complete week-by-week combined protocol The following protocol represents a conservative approach to introducing both compounds, designed to minimize GI side effects while building toward full therapeutic doses