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Compared to apoE3 and apoE2 (C112, C158), apoE4 (R112, R158) are impaired in stimulating cholesterol efflux (127-130) and in preventing inflammation and oxidation (117,124,131)

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For example, acyl-CoA oxidase (three isoforms - ACOX1, 2 and 3), the first enzyme in peroxisome oxidation transfers hydrogen to oxygen to make H 2 O 2 while carrying out a dehydrogenation reaction for the first ,-unsaturated intermediate, trans -2-enoyl-CoA

Different signaling pathways are important for the regulation of lamellocytes proliferation upon parasitism (Letourneau et al., 2016), including the Toll and Jak-Stat pathways (Morin-Poulard et al., 2013