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SIM refers to clinically diagnosed weakness in critically ill patients that cannot be attributed to non-critical illness causes, with an incidence rate as high as 40% among critically ill patients in the ICU (8,12)

GSH scavenges a wide range of ROS ( OH, H 2 O 2 , 1 O 2 ), and due to the very low value of electron reduction potential of the GSSG/GSH redox couple ( E = 264 mV at pH = 7.4) is GSH able to regenerate several important antioxidants, such as radicals of vitamins E and C back to their active non-radical forms (Jones 2002) (Fig