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We designed two peptides to enhance cellular uptake and facilitate nuclear localization by introducing CPP sequences
These effects support the stability of calcium signaling and homeostasis and indicate a treatment-induced neuroprotective effect against apoptosis, which is in line with previous studies showing a decrease in hippocampal apoptotic cell death and caspase activation caused by supplementation with N-3 PUFAs in aged rats, and by Vit D in rats exposed to other neurotoxic agents 84,85,86
The reduction in absorbance at 240 nm was recorded for 3 min at 30 s intervals for the assessment of catalase enzyme activity
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Specifically, the levels of type I collagen, elastin and sulfated GAGs are restored, although it does not cause a decrease in MMP1
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