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The ongoing clinical trial, the Restoring Insulin Secretion (RISE) Consortium, is testing whether placebo, metformin alone, liraglutide plus metformin, or insulin (3 months) followed by metformin (9 months) can preserve or improve beta cell function in individuals with early type 2 diabetes or prediabetes 48

Physicians continue prescribing them because evidence supports both safety and efficacy when sourced from licensed compounding pharmacies

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