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Am J Physiol Cell Physiol 290:C244253 Ghashghaeinia M, Koralkova P, Giustarini D et al (2020) The specific PKC- inhibitor chelerythrine blunts costunolide-induced eryptosis

In RANDs 2025 survey of users, ~52% reported nausea and ~34% diarrhea (mostly mild), and ~20% reported vomiting

Another study indicates that starting treatment with a lower dose and gradually increasing it helped reduce the incidence of gastrointestinal adverse events [64]