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Although GLP-1 RAs by themselves have a low risk of hypoglycemia, when used in combination with sulfonylureas and/or insulin, some experts recommend lowering the dose of sulfonylureas and short-acting and low-acting pancreatic islet analogs before or during the use of GLP-1 RAs ( Corresponding to the signal intensity for weight loss poor of GLP-1 RAs in our study, a network meta-analysis showed a decreasing trend in weight loss efficacy for tirzepatide, semaglutide, and liraglutide ( 4.2 Severe versus non-severe cases The most frequently reported adverse effects associated with GLP-1 RAs were gastrointestinal in nature

The good news: most patients report that nausea, constipation, and food aversions improve significantly within 48 weeks as the body adjusts to the medication

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It can also result from prolonged inadequate dietary intake in dogs on nutritionally limited diets