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19 General anesthesia is an important cause of esophagitis (sometimes leading to stricture formation) in cats, probably because gastroesophageal reflux appears to occur commonly in anesthetized cats.* For example, in a series of seven cats with benign esophageal stricture, recent anesthesia for ovariohysterectomy was the suspected cause in five cases
Other factors that can hinder A clearance include extracellular proprotein convertase subtilisin/kexin type 9 (PCSK9) impacting LRP1 on ECs and altered expression of -site amyloid precursor protein cleaving enzyme 1 (BACE1) [175, 176]
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