FDA-Approved Brand-Name Medications (via insurance): Wegovy (semaglutide) FDA-approved for weight loss Zepbound (tirzepatide) FDA-approved for weight loss Ozempic and Mounjaro (off-label for weight loss, via insurance) Compounded Alternatives (cash-pay, when appropriate): Compounded semaglutide, which may include glycine (to support muscle preservation) and Vitamin B12 (cyanocobalamin, to help reduce nausea) Compounded tirzepatide Oral Rybelsus (oral semaglutide) as an FDA-approved alternative for appropriate patients Zealthy states it does not offer commercially available copies of semaglutide or tirzepatide unless there is an official FDA-declared shortage, a policy commitment that, if maintained, would align with current post-shortage FDA regulations
For example, sarcosine was significant only after correcting for independent variables
Microbial metabolites such as SCFAs, neurotransmitters, and tryptophan derivatives act as mediators in this bidirectional dialog
Longevity and Other Speculative Benefits Some compound pharmacies are now advertising microdosed GLP-1 drugs to boost longevity or as an anti-addiction treatment, among other benefits that have not yet been endorsed by the FDA
Beta-cell function
